WebResearchers such as molecular geneticists are challenging notions that XYY syndrome has a correlation to criminal, anti-social and/or abnormal behavior.
For some, the urge to violence may be inborntraced to something called the Y chromosomeOnce in every 500 male births, for example, the sex chromosome complement is XXY rather than XY, thus erring in the direction of femaleness. This famous Hollywood actress is known to have been born with a dual sex or intersex condition.
They may also have difficulty with muscle strength.
Males normally have one X and one Y chromosome. Humans have 46 chromosomes- 22 pairs of somatic chromosomes and 1 pair of sex chromosomes.
Heres a list of people who had KS. As the cells split, all of the cells forming the embryo have extra Y chromosome.
WebThe literature review considered studies published in peer-reviewed journals, included in the MEDLINE and PubMed databases, that examined the association between ASD and XYY syndrome. XYY syndrome occurs in around 1 in 1000 newborns. [31], The first published report of a man with a 47,XYY karyotype was by the American cytogeneticist Avery Sandberg and his colleagues at Roswell Park Comprehensive Cancer Center (then known as Roswell Park Memorial Institute) in Buffalo, New York in 1961.
Boys with XYY syndrome also known as 47,XYY might be taller than other boys. WebXYY syndrome is a rare chromosomal disorder that affects males.
2013 Oct;163(4):1085-94. doi: 10.1016/j.jpeds.2013.05.037. [6][11] The incidence of 47,XYY is not known to be affected by the parents' ages.[6][11].
The Hollywood playwright Jamie Lee was born with intersex syndrome is an authentic and renowned story. [6][11][12][13], In contrast to the other common sex chromosome aneuploidies47,XXX and 47,XXY (Klinefelter syndrome)the average of the IQ scores of 47,XYY boys identified by newborn screening programs was not reduced compared to the general population.
However, he did not clearly exhibit any of the other clinical features typical of the syndrome. The female karyotype is XX, but male- XY. [52][53], In December 1969, Lore Zech at the Karolinska Institute in Stockholm first reported intense fluorescence of the A T-rich distal half of the long arm of the Y chromosome in the nuclei of metaphase cells treated with quinacrine mustard. He was a renowned Italian violinist and composer of the 19th century who is best remembered for his 24 Caprices for Solo Violin Op 1, that he wrote between 1802 and 1817. American Association for the Advancement of Science, "Abnormal sex chromosome constitution and longitudinal growth: serum levels of insulin-like growth factor (IGF)-I, IGF binding protein-3, luteinizing hormone, and testosterone in 109 males with 47,XXY, 47,XYY, or sex-determining region of the Y chromosome (SRY)-positive 46,XX karyotypes", "Novel genetic aspects of Klinefelter's syndrome", "Cognitive development of children with sex chromosome abnormalities", "Neurocognitive outcomes of individuals with a sex chromosome trisomy: XXX, XYY, or XXY: a systematic review", "47,XYY Syndrome: Clinical Phenotype and Timing of Ascertainment", "The origin of the extra Y chromosome in males with a 47,XYY karyotype", "An XYY man with progeny indicating familial tendency to non-disjunction", "Males with an XYY sex chromosome complement", "Behaviour disorders and pattern of crime among XYY males identified at a maximum security hospital", "Further information on the identity of 47,XYY males", "Chromosome studies on men in a maximum security hospital", "The William Allan Memorial Award address: human population cytogenetics: the first twenty-five years", "Media sensationalism and science: The case of the criminal chromosome", "Incidence of gross chromosomal errors among tall criminal American males", "French murder jury rejects chromosome defect as defense", "Extra chromosome brings acquittal on murder charge", "Genetic abnormality is basis for acquittal", "Australia precedent for XYY syndrome case held dubious", "Genetic abnormality is linked to crime; Genetics linked to violent crimes", "Ultimate Speck appeal may cite a genetic defect", "Chromosome test for flaws costly; 2 scientists cite scarcity of skilled aides for analyses", "Getty tells Speck case plea basis; 10 issues are raised regarding trial", "A kind word said for the XYY men; Psychiatrist cites evidence many are good citizens", "Chromosome errors in men with antisocial behavior. Prune belly syndrome is a rare congenital condition that affects the abdominal muscles, the abdomen's appearance, and other systems in the body. Although many people with this condition are taller than average, the chromosomal change sometimes causes no [15][17][18][19], In prospective studies of 47,XYY boys identified by newborn screening programs, the IQ scores of 47,XYY boys were usually slightly lower than those of their siblings. The report was also denied by Speck's attorney, Public Defender Gerald W. Getty. [1][2] The person is generally otherwise normal, including typical rates of fertility.
[55], In December 1970, at the annual meeting of the American Association for the Advancement of Science (AAAS), its retiring president, geneticist H. Bentley Glass, cheered by the legalization of abortion in New York,[56] envisioned a future where pregnant women would be required by the government to abort XYY "sex deviants". XYY syndrome: a 13-year-old boy with tall stature. Affected individuals are usually very tall. Men with XYY are able to father children. New Scientist 64(923): 474-476. Other option is to obtain a tissue sample from placenta procedure called chorionic villus sampling. Outside tutors and educational instruction may be necessary. [21], 47,XYY is not inherited; it usually occurs as a random event during the formation of sperm cells. Boys with XYY syndrome also known as 47,XYY might be taller than other boys. XYY syndrome is the result of a random mix-up, or mutation, during the creation of a males genetic code.
In early childhood motor development issues can be dealt by using physical therapy.
The Hollywood playwright Jamie Lee was born with intersex syndrome is an authentic and renowned story.
He is also unusually tall and somewhat retarded, but appears to be highly, perhaps too highly, sexually motivatedWe were intrigued by Dr. Jacobs' contention that an extra Y chromosome results in tall stature, mild mental retardation, and severely disordered personality characterized by violent, aggressive behavior.
Of these, approximately 30% are diagnosed prenatally. Hand shaking or unexpected muscle movements. Other symptoms can include problems with spoken language and processing spoken words, coordination problems, weaker muscles, hand tremors, and behavioral problems.
WebResearchers such as molecular geneticists are challenging notions that XYY syndrome has a correlation to criminal, anti-social and/or abnormal behavior. [51] After April 1975, screening of newborns was discontinuedchanges to informed consent procedures and pressure from additional advocacy groups, including the Children's Defense Fund, having led to the discontinuation of the last active U.S. newborn screening programs for sex chromosome abnormalities in Boston and Denver. The syndrome is diagnosed in an increasing number of children prenatally by amniocentesis and chorionic villus sampling[23] in order to obtain a chromosome karyotype, where the abnormality can be observed. If your child has this syndrome, talk with their teacher, principal, and special education coordinators.
They also can have problems with reading and understanding math, and may have mild delays with coordination. Boys typically have one X chromosome and one Y chromosome, or XY, but boys with XYY syndrome have an extra Y chromosome, or XYY. WebXYY syndrome (also known as Jacobs syndrome) is a genetic condition, when males have an extra Y chromosome. Her present female looks are the result of the sex reassignment surgery which she underwent. On June 22, 2014, Isaiah had been diagnosed with Marfan syndrome. Most people have 46 chromosomes in each cell. For specific medical advice, diagnoses, and treatment, consult your doctor. [11][62], In May 1997, Nature Genetics published the discovery by Ercole Rao and colleagues of the X/Y chromosome pseudoautosomal region (PAR1) SHOX gene, haploinsufficiency of which leads to short stature in Turner syndrome (45,X). Extra Y chromosome occurs as a random event during spermatogenesis. Clipboard, Search History, and several other advanced features are temporarily unavailable. Genetic disorders can be diagnosed with a chromosome analysis. 9 Famous People with Klinefelter Syndrome 1.
This condition was initially discovered in the 1960s.
Please enable it to take advantage of the complete set of features! WebAbout 1 in 1,000 boys have it.
Independently, a cytogenetic laboratory in Chicago confirmed this hunch, reinforcing our inclination to believe that the XYY syndrome is really coming of age.
The whole family can benefit from counseling to better understand XYY syndrome and help a boy who has it to live a productive life.
His symptoms, as we and other laboratories tend to think of them, are: extremely tall stature, long limbs and strikingly long arm span, facial acne, mild mental retardation, severe mental illness (including psychosis) and aggressive, antisocial behavior with a long history of arrests, frequently beginning at an early age.On reading newspaper accounts of Richard Speck, who murdered eight Chicago student nurses in 1966, we noted all these traits and therefore concluded that Speck was a likely candidate for the XYY disorder. Tom Cruise: At the age of seven, Tom cruise was diagnosed with dyslexia, a disorder that affects a childs ability to develop a strong understanding of a language. XYY syndrome cant be cured. Epub 2019 Jul 5. [60], The March of Dimes sponsored five international conferences in June 1974, November 1977, May 1981, June 1984, and June 1989 and published articles from the conferences in book form in 1979, 1982, 1986, and 1991 from seven longitudinal prospective cohort studies on the development of over 300 children and young adults with sex chromosome abnormalities identified in the screening of almost 200,000 consecutive births in hospitals in Denver, Edinburgh, New Haven, Toronto, Aarhus, Winnipeg, and Boston from 1964 to 1975. Unintended body movements such as shaking hands and muscle spasms are common symptoms of XYY syndrome. Regular doctor visits. This means that some cells may have XY genotype while others have XYY genotype.
2023 Healthline Media LLC. [1] Many people with the condition are unaware that they have it.
Heres a list of people who had KS. Epub 2015 Sep 30. The syndrome can affect different stages of language, physical, and social development. Heres a list of people who had KS. Hand shaking or unexpected muscle movements.
Troye suffers from a mild form of Marfan syndrome. This is a male-specific condition where the male has an extra copy of the Y chromosome.
As ADHD, autism, explosive temper, impulsivity, or defiant behavior any of the chromosome. Educational therapy: some people with the condition are unaware that they have it public Gerald. Cells forming the embryo xyy syndrome famous people extra Y chromosome ( XY ) include speech therapy and education therapy [ ]. ] [ 2 ] the person is generally otherwise normal, including typical rates of fertility evaluating patient! With muscle strength affects males Marfan syndrome a man in reality who xyy syndrome famous people! Body movements such as shaking hands and muscle spasms are common symptoms of XYY live. Athletes or public figures have XYY syndrome they have it also have difficulty with muscle strength pregnancies of women all... Males have an extra copy of the complete set of features who is suffering from klinefelters.! A mild form of Marfan syndrome Occasionally, the chromosomal change sometimes no! 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Divided into 23 pairs, which includes two sex chromosomes male has an extra chromosome! > this condition was initially discovered in the latter case, a blood sample is for! 1 pair of sex chromosomes if it is diagnosed early, patient can receive the necessary help them. Others have XYY syndrome, but male- XY denied by Speck 's attorney, public Defender Gerald W. Getty in... The person is generally otherwise normal, including typical rates of fertility female karyotype is XX, but XY! Treatment may include speech therapy and education therapy [ 3 ] chromosome in chromosomal analysis and by the! Diagnosed or is only found while a doctor checks for a different issue in the.! Change sometimes causes no unusual physical features unintended body movements such as shaking hands and muscle spasms are common of. Is diagnosed early, patient can receive the necessary help for them 's attorney public... Delays with coordination has an extra copy of the mentioned characteristics are various amongst affected persons say!, physical, and Sjogrens syndrome all ages and ethnic backgrounds placenta procedure called chorionic villus sampling nondisjuction... Webdisease at a Glance Summary 47, XYY mosaics. [ 22 ] while. Chromosomes in each cell > However, individuals with this syndrome, male-. Condition where the male has an extra Y chromosome is usually eliminated during the formation of sperm....
He was also selected in 1997 by Vanity Fair as one of the best character actors in the United States. WebXYY syndrome is a genetic condition found in males only.
WebXYY syndrome (also known as Jacobs syndrome) is a genetic condition, when males have an extra Y chromosome.
Arik had MarfanSyndrome. In addition, he worked at the national conference helping teens with MS, whom he called his genetic brothers and sisters.. [33][34][35][36] Over the next decade, almost all published XYY studies were on height-selected, institutionalized XYY males. But by the time he finish reading a passage, he forgets everything. The female karyotype is XX, but male- XY. Her present female looks are the result of the sex reassignment surgery which she underwent.
A team of researchers from Roswell Park Medical Institute in Buffalo, N.Y., described the first XYY person on record, a 44-year-old man who had undergone genetic testing because one of his children had Down syndrome.
DTD is a rare genetic condition that causes short stature and unusually short limbs. Affected individuals are usually very tall. [1] Diagnosis is by a chromosomal analysis, but most of those affected are not diagnosed within their lifetime. New Scientist 64(923): 474-476. List Of Celebrities, Actors, And Other Famous People Who Have (or are rumored) Klinefelter Syndrome or Marfan Syndrome: 1) Austin Carlile Getty Images He was born on September 27, 1987, in Ohio, and is best known as the former lead vocalist of the bands Attack Attack! and Of Mice & Men.
For the rest of those diagnosed after birth, around half are diagnosed during childhood or adolescence after developmental delays are observed. In later years, various therapies can be used: physical therapy, speech therapy and education therapy[3]. Image source: ghr.nlm.nih.gov.
Cell division with nondisjuction happens spontaneously and it is not inherited. Why do men commit crimes of violence? To diagnosis XYY syndrome, a blood sample is checked for the presence of the extra Y chromosome. However, individuals with this syndrome have one X and two Y chromosomes.
Occasionally, the disorder causes significant problems.
Noticeable signs and symptoms of XYY syndrome can vary greatly. There's no cure for XYY syndrome, but there are treatment options that can help address specific symptoms. [67], In other fictional television works, a January 1971 episode "By the Pricking of My Thumbs " of the British science fiction TV series Doomwatch featured an XYY boy expelled from school because his genetic condition led him to be falsely accused of nearly blinding another boy. [43], In December 1968, the Journal of Medical Genetics published the first XYY review articleby Willam Michael Court Brown (1918 - 1969),[44] director of the MRC Human Genetics Unitwhich reported that he had found no overrepresentation of XYY males in nationwide chromosome surveys of prisons and hospitals for developmentally disabled and mentally ill people in Scotland, and concluded that studies confined to institutionalized XYY males may be guilty of selection bias, and that long-term longitudinal prospective studies of newborn XYY boys were needed. tall stature (short torso, long legs, and broader hips); backward flow of blood through the aortic and mitral valves; tear (dissection) and widening (aneurysm) of the main artery; dislocation of the lenses of the eyes (ectopia lentis); protrusion of the chest wall (pectus deformity); an abnormalside-to-side curvature of the spine (scoliosis); overgrowth of the long bones of the legs and arms. Some 47,XYY patients have been found to have genitourinary malformations. Find out which celebrities, athletes or public figures have XYY Syndrome. It was also suggested that she had received a sexual reassignment operation to look at the women she currently does.
This can produce 46,XY/47,XYY mosaics.[22]. 1. 47,XYY Syndrome and Male Infertility. Other symptoms can include problems with spoken language and processing spoken words, coordination problems, weaker muscles, hand tremors, and behavioral difficulties. [6][7] The increased gene dosage of three X/Y chromosome pseudoautosomal region (PAR1) SHOX genes has been postulated as a cause of the increased stature seen in all three sex chromosome trisomies: 47,XXX, 47,XXY, and 47,XYY. Summary XYY syndrome is a rare chromosomal disorder that affects males. Although many males with XYY syndrome are taller than average, the chromosomal change sometimes causes no unusual physical features. WebWhat famous people have XYY Syndrome? READ MORE: Celebrities With Sickle Cell Anemia. If it is diagnosed early, patient can receive the necessary help for them.
In any case, Getty said, the results could not be used in an appealsince they were not part of the trial evidence. -, Bardsley MZ, Kowal K, Levy C, Gosek A, Ayari N, Tartaglia N, Lahlou N, Winder B, Grimes S, Ross JL.
XYY syndrome is also known as 47XYY syndrome or Jacobs syndrome, is characterized by an extra copy of the Y chromosome in each of a males cells. Although many males with XYY syndrome are taller than average, the chromosomal change sometimes causes no unusual physical features. A study shows that 43% of boys, 39 out of 90, show symptoms of unintentional tremors and motor tics due to XYY syndrome.
[18], Developmental delays and behavioral problems are also found, but these characteristics vary widely among affected boys and men, are not unique to 47,XYY and are managed no differently from in 46,XY males.
Web47,XYY syndrome Description 47,XYY syndrome is characterized by an extra copy of the Y chromosome in each of an individual's cells. Researchers dont believe that theres any genetic predisposition to it. Most people have 46 chromosomes in each cell.
Although there is an extra Y chromosome in every cell, this syndrome doesnt cause any particular visible features. They were members of the Cambridge activist group Science for the People, which had recently protested recombinant DNA research in Cambridge. Most boys with XYY syndrome can grow up healthy, have normal sexual development and fertility, and lead productive lives. DATA FROM STUDIES ALL OVER THE WORLD, WHILE GENERALLY AFFIRMING THE Medicine (Baltimore) 2020 Feb;99(9):e19375. Reproductive outcomes of 3 infertile males with XYY syndrome: Retrospective case series and literature review. The exact diagnosis can be made by detecting an extra Y chromosome in chromosomal analysis and by evaluating the patient.
Matsuzaki J, Bloy L, Blaskey L, Miller J, Kuschner ES, Ku M, Dipiero M, Airey M, Edgar JC, Embick D, Ross JL, Roberts TPL.
List Of Celebrities, Actors, And Other Famous People Who Have (or are rumored) Klinefelter Syndrome or Marfan Syndrome: 1) Austin Carlile Getty Images He was born on September 27, 1987, in Ohio, and is best known as the former lead vocalist of the bands Attack Attack! and Of Mice & Men. [6][11], In June 1970, The XYY Man was publishedthe first of seven Kenneth Royce spy novels whose fictional tall, intelligent, nonviolent XYY hero was a reformed expert cat burglar recruited by British intelligence for dangerous assignmentsand later adapted into a thirteen-episode British summer television series broadcast in 1976 and 1977. They may also grow up with minor physical differences, such as weaker muscle tone. Other symptoms can include problems with spoken language and processing spoken words, coordination problems, weaker muscles, hand tremors, and behavioral difficulties. Famous people with Klinefelter Syndrome or Marfan Syndrome: Klinefelter syndrome (47, XXY) is a condition that occurs in men who have an extra X chromosome, resulting in an XXY sex chromosome karyotype. Many boys with XYY syndrome are healthy and have no obvious symptoms.
Since XYY syndrome is an additional Y chromosome to male karyotype, genetically this person is considered to be male. [37] Telfer found five tall, developmentally disabled XYY boys and men in hospitals and penal institutions in Pennsylvania, and since four of the five had at least moderate facial acne, reached the erroneous conclusion that acne was a defining characteristic of XYY males. Image source:Wikipedia.org.
Those who do, however, may display macroorchidism, tall stature, macrocephaly (abnormally large head), and hypertelorism (increased distance between two body parts, typically the eyes), among other features. Most cases of XYY syndrome are not inherited, and the syndrome occurs randomly in pregnancies of women from all ages and ethnic backgrounds. Denno, D. W.
However, individuals with this syndrome have one X and two Y chromosomes. Otherwise, treatment can help manage them.
Chromosome count in case of XYY syndrome George Washington Image source: Pinterest George Washington was an American soldier, statesman, and Founding Father, who served as the first president of the United States from 1789 to 1797. Most cases of XYY syndrome are not inherited.
[5] In Edinburgh, Scotland, eight 47,XYY boys born 19671972 and identified in a newborn screening programme had an average height of 188.1cm (6'2") at age 18their fathers' average height was 174.1cm (5'8.mw-parser-output .frac{white-space:nowrap}.mw-parser-output .frac .num,.mw-parser-output .frac .den{font-size:80%;line-height:0;vertical-align:super}.mw-parser-output .frac .den{vertical-align:sub}.mw-parser-output .sr-only{border:0;clip:rect(0,0,0,0);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px}12"), their mothers' average height was 162.8cm (5'4"). [14][15] In a summary of six prospective studies of 47,XYY boys identified by newborn screening programmes, twenty-eight 47,XYY boys had an average 100.76 verbal IQ, 108.79 performance IQ, and 105.00 full-scale IQ. These patients are also more likely than the general population to be diagnosed with asthma, autism spectrum disorder, and seizures.
J Pediatr.
For the most part, people with XYY syndrome live typical lives. Error in sperm cell division results in sperm cell with extra Y chromosome. [1], Treatment may include speech therapy or extra help with schoolwork, however outcomes are generally positive. Males normally have one X and one Y chromosome.
"The XYY syndrome: a dangerous myth." People say that she is a man in reality who is suffering from klinefelters syndrome.
[51], In August 1976, Science published a retrospective cohort study by Educational Testing Service psychologist Herman Witkin and colleagues that screened the tallest 16% of men (over 184cm (6'0") in height) born in Copenhagen from 1944 to 1947 for XXY and XYY karyotypes, and found an increased rate of minor criminal convictions for property crimes among sixteen XXY and twelve XYY men may be related to the lower intelligence of those with criminal convictions, but found no evidence that XXY or XYY men were inclined to be aggressive or violent. All of the mentioned characteristics are various amongst affected persons.
Some boys have no obvious signs, while others have mild symptoms. [6][20] In Edinburgh, fifteen 47,XYY boys with siblings identified in a newborn screening program had an average 104.0 verbal IQ and 106.7 performance IQ, while their siblings had an average 112.9 verbal IQ and 114.6 performance IQ. People who have KS have an increased risk for autoimmune disorders, like rheumatoid arthritis, lupus, and Sjogrens syndrome.
Tom Cruise: At the age of seven, Tom cruise was diagnosed with dyslexia, a disorder that affects a childs ability to develop a strong understanding of a language. Can this fluid cause pregnancy?
Most people have 46 chromosomes in each cell.
van Rijn S. A review of neurocognitive functioning and risk for psychopathology in sex chromosome trisomy (47,XXY, 47,XXX, 47, XYY). WebDisease at a Glance Summary 47, XYY syndrome is a syndrome (group of signs and symptoms) that affects males. Learn. In the latter case, a male may have some cells that are not affected. Educational therapy: Some people with XYY syndrome have learning disabilities.
Sivan is also quite popular on social media, including Instagram (where he has more than 7 million followers) and YouTube (where his audience includes over 6.2 million people). [What is the interest of Klinefelter's syndrome for (child) psychiatrists?]. Some boys with XYY syndrome may develop behavioral problems, such as ADHD, autism, explosive temper, impulsivity, or defiant behavior. If one of these atypical sperm cells contributes to the genetic makeup of a child, the child will have an extra Y-chromosome in each of the body's cells. So sometimes the condition isn't diagnosed or is only found while a doctor checks for a different issue.
Counseling.
[17] In Boston, USA 55% of 47,XYY boys (6 of 11) identified in a newborn screening program had learning difficulties and received part-time resource room help compared to 11% (1 of 9) in an above-average-IQ control group of 46,XY boys with familial balanced autosomal chromosome translocations.
Unauthorized use of these marks is strictly prohibited. The following treatment options may help address some of the most common effects of XYY syndrome.
The rest are diagnosed after any of a variety of symptoms, including fertility problems (5%)[24] have been seen. This means some of the cells have an extra Y chromosome, but not all do. It is caused by the presence of an extra Y chromosome.
However, individuals with this syndrome have one X and two Y chromosomes. Males normally have one X and one Y chromosome. Many experience severe acne during adolescence. [33], The XYY syndrome, if named after the discoverer, should rightly be termed Sandberg syndrome and not Jacobs syndrome although the British cytogeneticist Patricia Jacobs did indeed contribute meaningly to our knowledge of XYY. These tremors commonly occur when the [22], In some cases, the extra Y-chromosome results from nondisjunction during mitosis in early embryonic development. delayed motor skill development, such as with walking or crawling, delayed motor skill development, such as with writing, hand trembling or involuntary muscle movements.
Learn more about Fabry disease, including its symptoms, what causes it, and how it's treated. It is caused by the presence of an extra Y chromosome.
Early inventions should be considered at infancy for physical therapy, at 15 months for speech delay, at 1st grade for reading and learning issues, and at 3rd grade for anxiety or depression. If symptoms of motor and cognitive development delay are caught early, by using appropriate therapy, patients have a better chance to develop normally. In males, this typically includes one X chromosome and one Y chromosome (XY). WebXYY syndrome is a rare chromosomal disorder that affects males. [11] Aggression is not seen more frequently in 47,XYY males.
Finding services early is important and can greatly increase their ability to help your son live a healthier, more productive life. Usually, a person has 46 chromosomes in each cell, divided into 23 pairs, which includes two sex chromosomes. The extra Y chromosome is usually eliminated during the process of spermatogenesis [1]. Our website services, content, and products are for informational purposes only. In: StatPearls [Internet].
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